SH2 Domain Binding: Diverse FLVRs of Partnership.
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ABSTRACT:
SUBMITTER: Jaber Chehayeb R
PROVIDER: S-EPMC7530234 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
SH2 Domain Binding: Diverse FLVRs of Partnership.
Jaber Chehayeb Rachel R Boggon Titus J TJ
Frontiers in endocrinology 20200918
The Src homology 2 (SH2) domain has a special role as one of the cornerstone examples of a "modular" domain. The interactions of this domain are very well-conserved, and have long been described as a bidentate, or "two-pronged plug" interaction between the domain and a phosphotyrosine (pTyr) peptide. Recent work has, however, highlighted unusual features of the SH2 domain that illustrate a greater diversity than was previously appreciated. In this review we discuss some of the novel and unusual ...[more]
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