Ontology highlight
ABSTRACT:
SUBMITTER: Di Trapani M
PROVIDER: S-EPMC6590341 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Di Trapani Mariano M Manaresi Nicolò N Medoro Gianni G
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20181201 12
Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Here, w ...[more]