Ontology highlight
ABSTRACT:
SUBMITTER: Funk C
PROVIDER: S-EPMC6590417 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Funk Christina C Raschbichler Verena V Lieber Diana D Wetschky Jens J Arnold Eileen K EK Leimser Jacqueline J Biggel Michael M Friedel Caroline C CC Ruzsics Zsolt Z Bailer Susanne M SM
Traffic (Copenhagen, Denmark) 20190111 2
Morphogenesis of herpesviral virions is initiated in the nucleus but completed in the cytoplasm. Mature virions contain more than 25 tegument proteins many of which perform both nuclear and cytoplasmic functions suggesting they shuttle between these compartments. While nuclear import of herpesviral proteins was shown to be crucial for viral propagation, active nuclear export and its functional impact are still poorly understood. To systematically analyze nuclear export of tegument proteins prese ...[more]