Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC6590834 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
PLoS pathogens 20190509 5
Enterovirus A71 (EV-A71) is a non-polio neurotropic enterovirus with pandemic potential. There are no antiviral agents approved to prevent or treat EV-A71 infections. We here report on the molecular mechanism by which a novel class of tryptophan dendrimers inhibits (at low nanomolar to high picomolar concentration) EV-A71 replication in vitro. A lead compound in the series (MADAL385) prevents binding and internalization of the virus but does not, unlike classical capsid binders, stabilize the pa ...[more]