Ontology highlight
ABSTRACT:
SUBMITTER: Zhou HH
PROVIDER: S-EPMC6930896 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhou Hai-Hong HH Chen Xu X Cai Lu-Ya LY Nan Xing-Wei XW Chen Jia-Hua JH Chen Xiu-Xiu XX Yang Yang Y Xing Zi-Hao ZH Wei Meng-Ning MN Li Yao Y Wang Sheng-Te ST Liu Kun K Shi Zhi Z Yan Xiao-Jian XJ
Frontiers in oncology 20191219
Overexpression of drug efflux transport ABCB1 is correlated with multidrug resistance (MDR) among cancer cells. Upregulation of ABCB1 accounts for the recurrence of resistance to docetaxel therapy in ovarian cancer with poor survival. Erastin is a novel and specific small molecule that targets SLC7A11 to induce ferroptosis. In the present research, we explored the synergistic effect of erastin and docetaxel in ovarian cancer. We confirmed that the co-delivery of erastin with docetaxel significan ...[more]