Ontology highlight
ABSTRACT:
SUBMITTER: Agudelo LZ
PROVIDER: S-EPMC6591322 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Agudelo Leandro Z LZ Ferreira Duarte M S DMS Dadvar Shamim S Cervenka Igor I Ketscher Lars L Izadi Manizheh M Zhengye Liu L Furrer Regula R Handschin Christoph C Venckunas Tomas T Brazaitis Marius M Kamandulis Sigitas S Lanner Johanna T JT Ruas Jorge L JL
Nature communications 20190624 1
The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid. This reduces kynurenine-associated neurotoxicity and generates glutamate as a byproduct. Here, we show that PGC-1α1 elevates aspartate and glutamate levels and increases the expression of glycolysis and malate-aspartate shuttle (MAS) genes. These inte ...[more]