Ontology highlight
ABSTRACT:
SUBMITTER: Lun S
PROVIDER: S-EPMC6591635 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lun Shichun S Tasneen Rokeya R Chaira Tridib T Stec Jozef J Onajole Oluseye K OK Yang Tian J TJ Cooper Christopher B CB Mdluli Khisi K Converse Paul J PJ Nuermberger Eric L EL Raj V Samuel VS Kozikowski Alan A Bishai William R WR
Antimicrobial agents and chemotherapy 20190624 7
Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of <i>Mycobacterium tuberculosis</i> In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and <i>in vivo</i> efficacy using an optimized oral formulation. Morphologically, indoleamide-treated <i>M. tuberculosis</i> cells demonstrated significantly higher numbers of dimples near the poles or septum, which may serve as the m ...[more]