Ontology highlight
ABSTRACT:
SUBMITTER: Adivarahan S
PROVIDER: S-EPMC6592633 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Adivarahan Srivathsan S Livingston Nathan N Nicholson Beth B Rahman Samir S Wu Bin B Rissland Olivia S OS Zenklusen Daniel D
Molecular cell 20181108 4
mRNAs form ribonucleoprotein complexes (mRNPs) by association with proteins that are crucial for mRNA metabolism. While the mRNP proteome has been well characterized, little is known about mRNP organization. Using a single-molecule approach, we show that mRNA conformation changes depending on its cellular localization and translational state. Compared to nuclear mRNPs and lncRNPs, association with ribosomes decompacts individual mRNAs, while pharmacologically dissociating ribosomes or sequesteri ...[more]