Ontology highlight
ABSTRACT:
SUBMITTER: Branco MA
PROVIDER: S-EPMC6592905 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20190625 1
Human induced pluripotent stem cells (hiPSCs) represent an almost limitless source of cells for disease modelling and drug screening applications. Here we established an efficient and robust 3D platform for cardiomyocyte (CMs) production from hiPSCs, solely through small-molecule-based temporal modulation of the Wnt signalling, which generates more than 90% cTNT<sup>+</sup> cells. The impact of performing the differentiation process in 3D conditions as compared to a 2D culture system, was charac ...[more]