The Dual-Specificity LAMMER Kinase Affects Stress-Response and Morphological Plasticity in Fungi.

ABSTRACT: The morphological plasticity of fungal pathogens has long been implicated in their virulence and is often influenced by extracellular factors. Complex signal transduction cascades are critical for sensing stresses imposed by external cues such as antifungal drugs, and for mediating appropriate cellular responses. Many of these signal transduction cascades are well-conserved and involve in the distinct morphogenetic processes during the life cycle of the pathogenic fungi. The dual-specificity LAMMER kinases are evolutionarily conserved across species ranging from yeasts to mammals and have multiple functions in various physiological processes; however, their functions in fungi are relatively unknown. In this review, we first describe the involvement of LAMMER kinases in cell surface changes

SUBMITTER: Lim JY 

PROVIDER: S-EPMC6593044 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature