Ontology highlight
ABSTRACT:
SUBMITTER: Do HQ
PROVIDER: S-EPMC6593142 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Do Hoa Quynh HQ Do Hoa Quynh HQ Hewetson Aveline A Myers Caitlyn C Khan Nazmul H NH Hastert Mary Catherine MC M Harsini Faraz F Latham Michael P MP Wylie Benjamin J BJ Sutton R Bryan RB Cornwall Gail A GA
Scientific reports 20190625 1
An amyloid matrix composed of several family 2 cystatins, including the reproductive cystatin CRES, is an integral structure in the mouse epididymal lumen and has proposed functions in sperm maturation and protection. Understanding how CRES amyloid assembles in vitro may provide clues on how the epididymal amyloid matrix forms in vivo. We therefore purified full-length CRES under nondenaturing conditions and followed its aggregation from monomer to amyloid under conditions that may approximate t ...[more]