Ontology highlight
ABSTRACT:
SUBMITTER: Palazzolo A
PROVIDER: S-EPMC6593778 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190306 15
A general approach for the efficient hydrogen-isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D<sub>2</sub> or T<sub>2</sub> as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerability. This novel method facilitates the access to essential diagnostic tools in drug discovery and development: tritiated pharmaceuticals with high specific activities and deuterat ...[more]