Differential toxicity of water versus gavage exposure to trichloroethylene in rats.
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ABSTRACT:
SUBMITTER: Stermer AR
PROVIDER: S-EPMC6594756 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Differential toxicity of water versus gavage exposure to trichloroethylene in rats.
Stermer Angela R AR Klein David D Wilson Shelby K SK Dalaijamts Chimeddulam C Bai Cathy Yue CY Hall Susan J SJ Madnick Samantha S Bianchi Enrica E Chiu Weihsueh A WA Boekelheide Kim K
Environmental toxicology and pharmacology 20190216
Trichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gavage exposures (1000 mg/kg/day) and through drinking water (0.6% TCE) for 14 weeks. The gavage route resulted in reversible reduction of epididymis weight, and reduced body weight that persisted for up to 12-weeks after cessation of exposure. Physiolo ...[more]
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