Ontology highlight
ABSTRACT:
SUBMITTER: Wegmann S
PROVIDER: S-EPMC6594764 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wegmann Susanne S Bennett Rachel E RE Delorme Louis L Robbins Ashley B AB Hu Miwei M McKenzie Danny D Kirk Molly J MJ Schiantarelli Julia J Tunio Nahel N Amaral Ana C AC Fan Zhanyun Z Nicholls Samantha S Hudry Eloise E Hyman Bradley T BT
Science advances 20190626 6
The incidence of Alzheimer's disease (AD), which is characterized by progressive cognitive decline that correlates with the spread of tau protein aggregation in the cortical mantle, is strongly age-related. It could be that age predisposes the brain for tau misfolding and supports the propagation of tau pathology. We tested this hypothesis using an experimental setup that allowed for exploration of age-related factors of tau spread and regional vulnerability. We virally expressed human tau local ...[more]