Ontology highlight
ABSTRACT:
SUBMITTER: Peschiera I
PROVIDER: S-EPMC6595007 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190626
Monoclonal antibody (mAb) cooperativity is a phenomenon triggered when mAbs couples promote increased bactericidal killing compared to individual partners. Cooperativity has been deeply investigated among mAbs elicited by factor H-binding protein (fHbp), a <i>Neisseria meningitidis</i> surface-exposed lipoprotein and one of the key antigens included in both serogroup B meningococcus vaccine Bexsero and Trumenba. Here we report the structural and functional characterization of two cooperative mAb ...[more]