Ontology highlight
ABSTRACT:
SUBMITTER: Maity S
PROVIDER: S-EPMC6597289 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Maity Sibaprasad S Lyubchenko Yuri L YL
Nanoscale 20190618 25
Amyloid β (Aβ) oligomers are formed at the early stages of the amyloidogenesis process and exhibit neurotoxicity. Development of oligomer specific therapeutics requires a detailed understanding of oligomerization processes. Amyloid oligomers exist transiently and single-molecule approaches are capable of characterizing such species. In this paper, we describe the application of an AFM based force clamp approach for probing of Aβ42 dimers. Aβ42 monomers were tethered to the AFM tip and surface an ...[more]