Ontology highlight
ABSTRACT:
SUBMITTER: Zimmermann M
PROVIDER: S-EPMC6597290 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zimmermann Michael M Zimmermann-Kogadeeva Maria M Wegmann Rebekka R Goodman Andrew L AL
Nature 20190603 7762
Individuals vary widely in their responses to medicinal drugs, which can be dangerous and expensive owing to treatment delays and adverse effects. Although increasing evidence implicates the gut microbiome in this variability, the molecular mechanisms involved remain largely unknown. Here we show, by measuring the ability of 76 human gut bacteria from diverse clades to metabolize 271 orally administered drugs, that many drugs are chemically modified by microorganisms. We combined high-throughput ...[more]