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Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution.

ABSTRACT: Sodium benzoate is one of the widely used food preservatives and its metabolism in the human body has been studied only with the host perspective. Despite the human gut microbiome being considered as a virtual human organ, its role in benzoate metabolism is yet to be elucidated. The current study uses a multi-omic approach to rationalize the role of human gut microbes in benzoate metabolism. Microbial diversity analysis with multiple features synchronously indicates the dominance of Bacteroidetes followed by Firmicutes, Actinobacteria, and Proteobacteria. Metagenomic exploration highlights the presence of benzoate catabolic protein features. These features were mapped on to the aerobic and anaerobic pathways of benzoate catabolism. Benzoate catabolism assays identified statistically significant metabolites (P?

SUBMITTER: Yadav M

PROVIDER: S-EPMC7946887 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution.

Yadav Monika M Lomash Avinash A Kapoor Seema S Pandey Rajesh R Chauhan Nar Singh NS

Scientific reports 20210310 1

Sodium benzoate is one of the widely used food preservatives and its metabolism in the human body has been studied only with the host perspective. Despite the human gut microbiome being considered as a virtual human organ, its role in benzoate metabolism is yet to be elucidated. The current study uses a multi-omic approach to rationalize the role of human gut microbes in benzoate metabolism. Microbial diversity analysis with multiple features synchronously indicates the dominance of Bacteroidete ...[more]

PMID: 33692426

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