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Central nervous system regeneration is driven by microglia necroptosis and repopulation.

ABSTRACT: Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

SUBMITTER: Lloyd AF

PROVIDER: S-EPMC6597360 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Lloyd Amy F AF Davies Claire L CL Holloway Rebecca K RK Labrak Yasmine Y Ireland Graeme G Carradori Dario D Dillenburg Alessandra A Borger Eva E Soong Daniel D Richardson Jill C JC Kuhlmann Tanja T Williams Anna A Pollard Jeffrey W JW des Rieux Anne A Priller Josef J Miron Veronique E VE

Nature neuroscience 20190610 7

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter r ...[more]

PMID: 31182869

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