Ontology highlight
ABSTRACT:
SUBMITTER: Dieguez-Hurtado R
PROVIDER: S-EPMC6597568 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature communications 20190627 1
Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mesenchymal cells that limit vascular permeability and protect the brain by preserving blood-brain barrier integrity. Loss of pericytes has been linked to neurodegenerative changes in genetically modified mice. Here, we report that postnatal inactivatio ...[more]