Ontology highlight
ABSTRACT:
SUBMITTER: Roth C
PROVIDER: S-EPMC6598640 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Roth Claude C Cantaert Tineke T Colas Chloé C Prot Matthieu M Casadémont Isabelle I Levillayer Laurine L Thalmensi Jessie J Langlade-Demoyen Pierre P Gerke Christiane C Bahl Kapil K Ciaramella Giuseppe G Simon-Loriere Etienne E Sakuntabhai Anavaj A
Frontiers in immunology 20190621
Dengue virus (DENV) induces strong T and B cell responses upon infection. Hence, it is difficult to determine the contribution of cell-mediated immunity alone in the long lasting protection against DENV infection and disease. Numerous CD4+ and CD8+ T cell epitopes have been identified, mainly in the non-structural proteins of DENV. Taking into account the immunogenicity and peptide sequence conservation among the different DENV serotypes, a minimal DENV antigen, called DENV1-NS, has been designe ...[more]