Ontology highlight
ABSTRACT:
SUBMITTER: Chu H
PROVIDER: S-EPMC6599017 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chu Hongqian H Zhao Jian J Mi Yongsheng Y Di Zhenghan Z Li Lele L
Nature communications 20190628 1
Immunomodulatory therapies are becoming a paradigm-shifting treatment modality for cancer. Despite promising clinical results, cancer immunotherapy is accompanied with off-tumor toxicity and autoimmune adverse effects. Thus, the development of smarter systems to regulate immune responses with superior spatiotemporal precision and enhanced safety is urgently needed. Here we report an activatable engineered immunodevice that enables remote control over the antitumor immunity in vitro and in vivo w ...[more]