Ontology highlight
ABSTRACT:
SUBMITTER: Ma C
PROVIDER: S-EPMC6599042 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ma Chengying C Wu Xiaofei X Sun Dongjie D Park Eunyong E Catipovic Marco A MA Rapoport Tom A TA Gao Ning N Li Long L
Nature communications 20190628 1
The Sec61/SecY channel allows the translocation of many proteins across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane. In bacteria, most secretory proteins are transported post-translationally through the SecY channel by the SecA ATPase. How a polypeptide is moved through the SecA-SecY complex is poorly understood, as structural information is lacking. Here, we report an electron cryo-microscopy (cryo-EM) structure of a translocating SecA-SecY complex in a lipi ...[more]