Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen NB
PROVIDER: S-EPMC6599573 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nguyen Ngoc B NB Chen Cheng-Han CH Zhang Yulong Y Zhao Peng P Wu Benjamin M BM Ardehali Reza R
Nanomedicine : nanotechnology, biology, and medicine 20190423
Ligand-dependent Cre recombinases are pivotal tools for the generation of inducible somatic mutants. This method enables spatial and temporal control of gene activity through tamoxifen administration, providing new avenues for studying gene function and establishing animal models of human diseases. While this paved the way for developmental studies previously deemed impractical, the generation of tissue-specific transgenic mouse lines can be time-consuming and costly. Herein, we design a 'smart' ...[more]