Ontology highlight
ABSTRACT:
SUBMITTER: Lee HM
PROVIDER: S-EPMC6600415 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lee Hye Min HM Kwon Soon Bin SB Son Ahyun A Kim Doo Hyun DH Kim Kyun-Hwan KH Lim Jonghyo J Kwon Young-Guen YG Kang Jin Sun JS Lee Byung Kyu BK Byun Young Ho YH Seong Baik L BL
International journal of molecular sciences 20190611 11
Intrinsic disorders are a common feature of hub proteins in eukaryotic interactomes controlling the signaling pathways. The intrinsically disordered proteins (IDPs) are prone to misfolding, and maintaining their functional stability remains a major challenge in validating their therapeutic potentials. Considering that IDPs are highly enriched in RNA-binding proteins (RBPs), here we reasoned and confirmed that IDPs could be stabilized by fusion to RBPs. Dickkopf2 (DKK2), Wnt antagonist and a prot ...[more]