Ontology highlight
ABSTRACT:
SUBMITTER: Rey J
PROVIDER: S-EPMC6602448 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Rey Julien J Rasolohery Inès I Tufféry Pierre P Guyon Frédéric F Moroy Gautier G
Nucleic acids research 20190701 W1
The large number of proteins found in the human body implies that a drug may interact with many proteins, called off-target proteins, besides its intended target. The PatchSearch web server provides an automated workflow that allows users to identify structurally conserved binding sites at the protein surfaces in a set of user-supplied protein structures. Thus, this web server may help to detect potential off-target protein. It takes as input a protein complexed with a ligand and identifies with ...[more]