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PRECOG: PREdicting COupling probabilities of G-protein coupled receptors.


ABSTRACT: G-protein coupled receptors (GPCRs) control multiple physiological states by transducing a multitude of extracellular stimuli into the cell via coupling to intra-cellular heterotrimeric G-proteins. Deciphering which G-proteins couple to each of the hundreds of GPCRs present in a typical eukaryotic organism is therefore critical to understand signalling. Here, we present PRECOG (precog.russelllab.org): a web-server for predicting GPCR coupling, which allows users to: (i) predict coupling probabilities for GPCRs to individual G-proteins instead of subfamilies; (ii) visually inspect the protein sequence and structural features that are responsible for a particular coupling; (iii) suggest mutations to rationally design artificial GPCRs with new coupling properties based on predetermined coupling features.

SUBMITTER: Singh G 

PROVIDER: S-EPMC6602504 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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PRECOG: PREdicting COupling probabilities of G-protein coupled receptors.

Singh Gurdeep G   Inoue Asuka A   Gutkind J Silvio JS   Russell Robert B RB   Russell Robert B RB   Raimondi Francesco F  

Nucleic acids research 20190701 W1


G-protein coupled receptors (GPCRs) control multiple physiological states by transducing a multitude of extracellular stimuli into the cell via coupling to intra-cellular heterotrimeric G-proteins. Deciphering which G-proteins couple to each of the hundreds of GPCRs present in a typical eukaryotic organism is therefore critical to understand signalling. Here, we present PRECOG (precog.russelllab.org): a web-server for predicting GPCR coupling, which allows users to: (i) predict coupling probabil  ...[more]

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