Pre-diagnostic 25-hydroxyvitamin D levels and survival in cancer patients.

ABSTRACT: PURPOSE:Our main aim was to explore whether pre-diagnostic circulating levels of 25-hydroxyvitamin D (25(OH)D) among older individuals with cancer were associated with overall and cancer-specific survival after diagnosis. DESIGN:We used data from the Reykjavik-AGES Study on participants (n?=?4,619) without cancer at entry, when blood samples were taken for 25(OH)D standardized measurements. The association with cancer risk, all-cause- and cancer-specific mortality was assessed among those later diagnosed with cancer, comparing four 25(OH)D categories, using 50-69.9 nmol/L as the reference category. RESULTS:Cancer was diagnosed in 919 participants on average 8.3 years after blood draw. No association was observed between the reference group and other 25(OH)D groups and total cancer incidence. Mean age at diagnosis was 80.9 (±?5.7) years. Of those diagnosed, 552 died during follow-up, 67% from cancer. Low pre-diagnostic levels of 25(OH)D?

SUBMITTER: Torfadottir JE 

PROVIDER: S-EPMC6602548 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature