Low 25-hydroxyvitamin D levels and cognitive impairment in hemodialysis patients.

ABSTRACT:

Background and objectives

25-hydroxyvitamin D (25[OH]D) deficiency and cognitive impairment are both prevalent in hemodialysis patients in the United States. This study tested the hypothesis that 25(OH)D deficiency may be associated with cognitive impairment because of its vasculoprotective, neuroprotective, and immune-modulatory properties.

Design, setting, participants, & measurements

This cross-sectional analysis involved 255 patients enrolled in the Dialysis and Cognition Study between 2004 and 2012. In linear regression models, 25(OH)D was the exposure variable; it was used first as a continuous variable and then stratified as deficient (<12 ng/ml), insufficient (12 to <20 ng/ml), and sufficient (≥20 ng/ml). Principal component analysis was used to obtain the memory and

SUBMITTER: Shaffi K 

PROVIDER: S-EPMC3675858 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature