Ontology highlight
ABSTRACT:
SUBMITTER: Mittal N
PROVIDER: S-EPMC6603046 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mittal Nishant N Yoon Sung Han SH Enomoto Hirokazu H Hiroshi Miyama M Shimizu Atsushi A Kawakami Atsushi A Fujita Misato M Watanabe Hideto H Fukuda Keiichi K Makino Shinji S
Scientific reports 20190701 1
Versican is an evolutionary conserved extracellular matrix proteoglycan, and versican expression loss in mice results in embryonic lethality owing to cardiovascular defects. However, the in utero development of mammals limits our understanding of the precise role of versican during cardiovascular development. Therefore, the use of evolutionarily distant species that develop ex utero is more suitable for studying the mechanistic basis of versican activity. We performed ENU mutagenesis screening t ...[more]