Ontology highlight
ABSTRACT:
SUBMITTER: Trammell R
PROVIDER: S-EPMC6603193 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Trammell Rachel R D'Amore Lorenzo L Cordova Alexandra A Polunin Pavel P Xie Nan N Siegler Maxime A MA Belanzoni Paola P Swart Marcel M Garcia-Bosch Isaac I
Inorganic chemistry 20190514 11
The use of copper for C-H bond functionalization, compared to other metals, is relatively unexplored. Herein, we report a synthetic protocol for the regioselective hydroxylation of sp<sup>2</sup> and sp<sup>3</sup> C-H bonds using a directing group, stoichiometric amounts of Cu and H<sub>2</sub>O<sub>2</sub>. A wide array of aromatic ketones and aldehydes are oxidized in the carbonyl γ-position with remarkable yields. We also expanded this methodology to hydroxylate the β-position of alkylic ket ...[more]