Ontology highlight
ABSTRACT:
SUBMITTER: Gentile F
PROVIDER: S-EPMC6603245 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in neuroscience 20190625
Although amyotrophic lateral sclerosis (ALS) has been considered as a disorder of the motor neuron (MN) cell body, recent evidences show the non-cell-autonomous pathogenic nature of the disease. Axonal degeneration, loss of peripheral axons and destruction of nerve terminals are early events in the disease pathogenic cascade, anticipating MN degeneration, and the onset of clinical symptoms. Therefore, although ALS and peripheral axonal neuropathies should be differentiated in clinical practice, ...[more]