Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC7308438 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Zhouyang Z Cheng Xi X Zhong Shanshan S Zhang Xiuchun X Liu Chang C Liu Fangxi F Zhao Chuansheng C
Frontiers in neuroscience 20200616
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by muscle weakness due to the degeneration of the upper and lower motor neurons. Neuroinflammation is known as a prominent pathological feature of ALS. Although neuroinflammation cannot trigger ALS, activated central nervous system (CNS) microglia and astrocytes, proinflammatory periphery monocytes/macrophages and T lymphocytes, and infiltrated monocytes/macrophages and T lymphocytes, as well as the immunoreac ...[more]