Animal models of necrotizing enterocolitis: review of the literature and state of the art.
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SUBMITTER: Sulistyo A
PROVIDER: S-EPMC6604570 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
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Animal models of necrotizing enterocolitis: review of the literature and state of the art.
Sulistyo Adrienne A Rahman Abidur A Biouss George G Antounians Lina L Zani Augusto A
Innovative surgical sciences 20180310 2
Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal surgical emergency in preterm neonates. Over the last five decades, a variety of experimental models have been developed to study the pathophysiology of this disease and to test the effectiveness of novel therapeutic strategies. Experimental NEC is mainly modeled in neonatal rats, mice and piglets. In this review, we focus on these experimental models and discuss the major advantages and disadvantages of each. We also ...[more]
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