Ontology highlight
ABSTRACT:
SUBMITTER: Gupta R
PROVIDER: S-EPMC6606008 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Gupta Riya R Bhatt Lokesh Kumar LK Johnston Thomas P TP Prabhavalkar Kedar S KS
Cancer biology & therapy 20190503 8
Despite incessant research, colon cancer still is one of the most common causes of fatalities in both men and women worldwide. Also, nearly 50% of patients with colorectal cancer show tumor recurrence. Recent investigations have highlighted the involvement of colon cancer stem cells (CCSCs) in cancer relapse and chemoresistance. CCSCs deliver a significant protumorigenic niche through persistent overexpression of self-renewal capabilities. Moreover, CSCs cross network with stromal cells, immune ...[more]