Ontology highlight
ABSTRACT:
SUBMITTER: Anderson HE
PROVIDER: S-EPMC6606055 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Anderson Hans E HE Schaller Kristin L KL Caldwell John H JH Weir Richard F Ff RFF
Neuroscience letters 20190509
Adenoassociated viral vectors provide a safe and robust method for expression of transgenes in nondividing cells such as neurons. Intravenous injections of these vectors provide a means of transducing motoneurons of peripheral nerves. Previous research has demonstrated that serotypes 1, rh10 and PHP.B can transduce motor neuron cell bodies in the spinal cord, but has not quantified expression in the peripheral nerve axon. Axonal labeling is crucial for optogenetic stimulation and detection of ac ...[more]