Ontology highlight
ABSTRACT:
SUBMITTER: Dunce JM
PROVIDER: S-EPMC6606445 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Dunce James M JM Dunne Orla M OM Ratcliff Matthew M Millán Claudia C Madgwick Suzanne S Usón Isabel I Davies Owen R OR
Nature structural & molecular biology 20180618 7
Meiotic chromosomes adopt unique structures in which linear arrays of chromatin loops are bound together in homologous chromosome pairs by a supramolecular protein assembly, the synaptonemal complex. This three-dimensional scaffold provides the essential structural framework for genetic exchange by crossing over and subsequent homolog segregation. The core architecture of the synaptonemal complex is provided by SYCP1. Here we report the structure and self-assembly mechanism of human SYCP1 throug ...[more]