Ontology highlight
ABSTRACT:
SUBMITTER: Nik ME
PROVIDER: S-EPMC6606580 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nik Maryam Ebrahimi ME Malaekeh-Nikouei Bizhan B Amin Mohamadreza M Hatamipour Mahdi M Teymouri Manouchehr M Sadeghnia Hamid Reza HR Iranshahi Mehrdad M Jaafari Mahmoud Reza MR
Scientific reports 20190702 1
Galbanic acid (Gba), a sesquiterpene coumarin, with strong antiangiogenic activity could serve as an excellent anti-cancer agent. However, Gba is a poor water-solube which hampered its clinical application. In this study, a pegylated liposomal Gba (PLGba) with HSPC/Cholesterol/mPEG<sub>2000</sub>-DSPE (56.2, 38.3, 5.3% molar ratio) was developed by the thin film hydration plus extrusion and calcium acetate gradient remote loading method, to address the issue of poor Gba solubility. Moreover, an ...[more]