Ontology highlight
ABSTRACT:
SUBMITTER: Descalzi G
PROVIDER: S-EPMC6606643 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Descalzi Giannina G Gao Virginia V Steinman Michael Q MQ Suzuki Akinobu A Alberini Cristina M CM
Communications biology 20190702
Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally replace lactate in rescuing memory impairment caused by inhibition of glycogenolysis or expression knockdown of glia monocarboxylate transporters (MCTs) 1 and 4 in the dorsal hippocampus of rats. In contrast, either metabolite is unable to rescue me ...[more]