Ontology highlight
ABSTRACT:
SUBMITTER: Carrieri FA
PROVIDER: S-EPMC6607002 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Carrieri Francesca Anna FA Murray Philip J PJ Ditsova Dimitrinka D Ferris Margaret Ashley MA Davies Paul P Dale Jacqueline Kim JK
EMBO reports 20190417 7
All vertebrates share a segmented body axis. Segments form from the rostral end of the presomitic mesoderm (PSM) with a periodicity that is regulated by the segmentation clock. The segmentation clock is a molecular oscillator that exhibits dynamic clock gene expression across the PSM with a periodicity that matches somite formation. Notch signalling is crucial to this process. Altering Notch intracellular domain (NICD) stability affects both the clock period and somite size. However, the mechani ...[more]