The role of adjuvant treatment in early-stage oral cavity squamous cell carcinoma: An international collaborative study.

ABSTRACT: BACKGROUND:Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC. METHODS:Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis. RESULTS:Of 1257 patients with T1-2N0M0 disease, 33 (2.6%) had positive margins, and 205 (16.3%) had close margins. The 5-year OS rate was 80% for patients with clear margins, 52% for patients with close margins, and 63% for patients with positive margins (P?2-fold increase in the risk of recurrence (P?

SUBMITTER: Fridman E 

PROVIDER: S-EPMC6607430 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature