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Prognostic value of DNA aneuploidy in gastric cancer: a meta-analysis of 3449 cases.


ABSTRACT: BACKGROUND:DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA ploidy status on the survival of gastric cancer patients. METHODS:We used PubMed and Web of Science databases to retrieve relevant articles. The correlation between DNA aneuploidy and the clinicopathological features of gastric cancer, such as stage, depth of invasion (T), lymph node metastasis (N), distant metastasis (M), differentiation (G), tumor types (Lauren classification) and overall survival (OS) were evaluated. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were collected carefully from each article OS was presented with HRs. The relationships between DNA aneuploidy and each characteristic were analyzed using risk ratios (RR) and a 95% confidence interval (CI). Significance was established using P?

SUBMITTER: Xu J 

PROVIDER: S-EPMC6607593 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Prognostic value of DNA aneuploidy in gastric cancer: a meta-analysis of 3449 cases.

Xu Jing J   Zhu Ruolin R   Fan Lulu L   Ge Shangqing S   Wei Wei W   Li Xiaoqiu X   Da Liangshan L   Jia Zhenya Z   Zhao Zhiyan Z   Ning Jie J   Da Jie J   Peng Wanren W   Gu Kangsheng K   Sun Guoping G  

BMC cancer 20190702 1


<h4>Background</h4>DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA ploidy status on the survival of gastric cancer patients.<h4>Methods</h4>We used PubMed and Web of Science databases to retrieve relevant articles. The correlation between DNA aneuploidy and the clinicopathological features of gastric cancer, such as stage, depth of invasion  ...[more]

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