Neurodegeneration by activation of the microglial complement-phagosome pathway.
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ABSTRACT:
SUBMITTER: Bodea LG
PROVIDER: S-EPMC6608212 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Neurodegeneration by activation of the microglial complement-phagosome pathway.
Bodea Liviu-Gabriel LG Wang Yiner Y Linnartz-Gerlach Bettina B Kopatz Jens J Sinkkonen Lasse L Musgrove Ruth R Kaoma Tony T Muller Arnaud A Vallar Laurent L Di Monte Donato A DA Balling Rudi R Neumann Harald H
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140601 25
Systemic inflammatory reactions have been postulated to exacerbate neurodegenerative diseases via microglial activation. We now demonstrate in vivo that repeated systemic challenge of mice over four consecutive days with bacterial LPS maintained an elevated microglial inflammatory phenotype and induced loss of dopaminergic neurons in the substantia nigra. The same total cumulative LPS dose given within a single application did not induce neurodegeneration. Whole-genome transcriptome analysis of ...[more]
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