Ontology highlight
ABSTRACT:
SUBMITTER: Ambrose AJ
PROVIDER: S-EPMC6608569 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20190520 14
Glucose-regulated protein 78 (GRP78) is the ER resident 70 kDa heat shock protein 70 (HSP70) and has been hypothesized to be a therapeutic target for various forms of cancer due to its role in mitigating proteotoxic stress in the ER, its elevated expression in some cancers, and the correlation between high levels for GRP78 and a poor prognosis. Herein we report the development and use of a high throughput fluorescence polarization-based peptide binding assay as an initial step toward the discove ...[more]