Ontology highlight
ABSTRACT:
SUBMITTER: Patwardhan CA
PROVIDER: S-EPMC4836055 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Patwardhan Chaitanya A CA Alfa Eyad E Lu Su S Chadli Ahmed A
Journal of biomolecular screening 20140902 2
Hsp90 and its co-chaperones are known to be important for cancer cell survival. The N-terminal inhibitors of Hsp90 that are in ongoing clinical trials as antitumor agents have unfortunately shown disappointing efficacies in the clinic. Thus, novel inhibitors of the Hsp90 machine with a different mechanism of action are urgently needed. We report here the development of a novel high-throughput screening assay platform to identify small-molecule inhibitors of Hsp90 and its co-chaperones. This assa ...[more]