Ontology highlight
ABSTRACT:
SUBMITTER: Lee YS
PROVIDER: S-EPMC6609217 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lee Yun Sok YS Riopel Matthew M Cabrales Pedro P Bandyopadhyay Guatam K GK
Science advances 20190703 7
The decrease in incretin effects is an important etiologic component of type 2 diabetes with unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen homeostasis, we found that liver HIF-1α expression was increased mainly by soluble factors released from obese adipocytes, leading to decreased incretin effects. Deletion of hepatocyte HIF-1α protected obesity-induced glucose intolerance without changes in body weight, liver steatosis, or insulin resistance. In-depth ...[more]