Ontology highlight
ABSTRACT:
SUBMITTER: Minn I
PROVIDER: S-EPMC6609218 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Minn Il I Huss David J DJ Ahn Hye-Hyun HH Chinn Tamara M TM Park Andrew A Jones Jon J Brummet Mary M Rowe Steven P SP Sysa-Shah Polina P Du Yong Y Levitsky Hyam I HI Pomper Martin G MG
Science advances 20190703 7
Chimeric antigen receptor (CAR) T cell therapy for hematologic malignancies is fraught with several unknowns, including number of functional T cells that engage target tumor, durability and subsequent expansion and contraction of that engagement, and whether toxicity can be managed. Non-invasive, serial imaging of CAR T cell therapy using a reporter transgene can address those issues quantitatively. We have transduced anti-CD19 CAR T cells with the prostate-specific membrane antigen (PSMA) becau ...[more]