Ontology highlight
ABSTRACT:
SUBMITTER: Minn I
PROVIDER: S-EPMC6609218 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Science advances 20190703 7
Chimeric antigen receptor (CAR) T cell therapy for hematologic malignancies is fraught with several unknowns, including number of functional T cells that engage target tumor, durability and subsequent expansion and contraction of that engagement, and whether toxicity can be managed. Non-invasive, serial imaging of CAR T cell therapy using a reporter transgene can address those issues quantitatively. We have transduced anti-CD19 CAR T cells with the prostate-specific membrane antigen (PSMA) becau ...[more]