Dataset Information

How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments.

ABSTRACT: Exposure to light has short- and long-term impacts on non-visual responses in humans. While many aspects related to non-visual light sensitivity have been characterised (such as the action spectrum for melatonin suppression), much remains to be elucidated. Here, we provide a set of minimum reporting guidelines for reporting the stimulus conditions involving light as an intervention in chronobiology, sleep research and environmental psychology experiments. Corresponding to the current state-of-the-art knowledge (June 2019), these are (i) measure and report the spectral power distribution of the acute stimulus from the observer's point of view; (ii) measure and report the spectral power distribution of the background light environment from the observer's point of view; (iii), make spectra available in tabulated form, (iv) report ?-opic (ir)radiances and illuminance; (v) describe the timing properties of stimulus (duration and pattern); (vi) describe the spatial properties of stimulus (spatial arrangement and extent), and (vii) report measurement conditions and equipment. We supplement the minimum reporting guidelines with optional reporting suggestions and discuss limitations of the reporting scheme.

SUBMITTER: Spitschan M

PROVIDER: S-EPMC6609447 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments.

Spitschan Manuel M Stefani Oliver O Blattner Peter P Gronfier Claude C Lockley Steven W SW Lucas Robert J RJ

Clocks & sleep 20190626 3

Exposure to light has short- and long-term impacts on non-visual responses in humans. While many aspects related to non-visual light sensitivity have been characterised (such as the action spectrum for melatonin suppression), much remains to be elucidated. Here, we provide a set of minimum reporting guidelines for reporting the stimulus conditions involving light as an intervention in chronobiology, sleep research and environmental psychology experiments. Corresponding to the current state-of-th ...[more]

PMID: 31281903

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Project description:The circadian rhythm, called Process C, regulates a wide range of biological processes in humans including sleep, metabolism, body temperature, and hormone secretion. Light is the dominant synchronizer of the circadian rhythm-it has been used to regulate the circadian phase to cope with jet-lag, shift work, and sleep disorder. The homeostatic oscillation of the sleep drive is called Process S. Process C and Process S together determine the sleep-wake cycle in what is known as the two-process model. This paper addresses the regulation of both Process C and Process S by scheduling light exposure and sleep based on numerical simulations of circadian rhythm and sleep mathematical models. This is a significant step beyond the existing literature that only considers the entrainment of Process C. Regulation of the two-process model poses several unique features and challenges: 1. Process S is non-smooth, i.e., the homeostatic dynamics are different in the sleep and wake regimes; 2. Light only indirectly affects Process S through Process C; 3. Light does not affect Process C during sleep. We consider two scenarios: optimizing light intensity as the control input with spontaneous (i.e., unscheduled) sleep/wake times and jointly optimizing the light intensity and the sleep/wake times, which allows limited delayed sleep and early waking as part of the decision variables. We solve the time-optimal entrainment problem for the two-process model for both scenarios using an extension of the gradient descent algorithm to non-smooth systems. To illustrate the efficacy of our time-optimal entrainment strategies, we consider two common use cases: transmeridian travelers and shift workers. For transmeridian travelers, joint optimization of the two-process model avoids the unrealistic long wake duration when only Process C is considered. The entrainment time also decreases when both the light input and the sleep schedule are optimized compared to when only the light input is optimized. For shift workers, we show that the entrainment time is significantly shortened by optimizing the night shift working light.

Dataset Information

How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments.

Publications

How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments.

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