MicroRNA signature refine response prediction in CML.
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ABSTRACT:
SUBMITTER: Alves R
PROVIDER: S-EPMC6609611 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
MicroRNA signature refine response prediction in CML.
Alves Raquel R Gonçalves Ana Cristina AC Jorge Joana J Marques Gilberto G Luís Dino D Ribeiro André B AB Freitas-Tavares Paulo P Oliveiros Bárbara B Almeida António M AM Sarmento-Ribeiro Ana Bela AB
Scientific reports 20190704 1
microRNAs (miRs) dysregulation have emerged as a crucial step in tumorigenesis, being related with cancer development, progression and response to treatment. In chronic myeloid leukaemia (CML), the resistance to tyrosine kinase inhibitors (TKI) is responsible for treatment failure and could be linked to changes in miRs expression. This work aimed to correlate the expression levels of 3 miRs, miR-21, miR-26b and miR-451, with response to TKI treatment in CML patients. miR-451 levels at diagnosis ...[more]
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