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Gene expression-based imatinib response prediction in chronic phase CML

ABSTRACT: Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) is guided by the pre-defined European Leukemia Net (ELN) or other response criteria. This allows patient stratification only during but not prior to treatment initiation. Gene expression profiling (GEP)-based response prediction might become a valuable tool for patient stratification in CML, but so far published data for response prediction are conflicting. We generated an imatinib response predicting gene signature by GEP from peripheral blood samples of pre-treated CML patients in late chronic phase.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44589 | GEO | 2021/12/31

REPOSITORIES: GEO

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